Frequently Asked
Common questions about (E)-3-Iodo-2-propenoic acid
What is (E)-3-Iodo-2-propenoic acid used for?
(E)-3-Iodo-2-propenoic acid is an iodo-substituted compound offering high reactivity in metal-mediated transformations used primarily in the pharmaceutical and nuclear medicine industries. Key applications include sonogashira and heck coupling with the lowest activation barrier among aryl halides and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.
Where can I buy (E)-3-Iodo-2-propenoic acid in the USA?
ChemContract Research is a trusted USA-based supplier of (E)-3-Iodo-2-propenoic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for (E)-3-Iodo-2-propenoic acid?
ChemContract Research supplies (E)-3-Iodo-2-propenoic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize (E)-3-Iodo-2-propenoic acid in custom quantities?
Yes. ChemContract Research offers custom synthesis services for (E)-3-Iodo-2-propenoic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with (E)-3-Iodo-2-propenoic acid?
For amide bond formation from the carboxylic acid in (E)-3-Iodo-2-propenoic acid, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
What coupling reactions can I run with (E)-3-Iodo-2-propenoic acid?
As a iodinated compound, (E)-3-Iodo-2-propenoic acid is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
How should I store (E)-3-Iodo-2-propenoic acid?
Store refrigerated (2–8 °C) in a light-resistant, tightly sealed container under inert atmosphere to prevent degradation. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
