Accelerate discovery through high-throughput parallel synthesis, rapid optimization, and integrated screening workflows.
ChemContract's combinatorial and automated synthesis platform enables rapid library design, synthesis, and screening at unprecedented scale. Our state-of-the-art automation technology generates hundreds to thousands of compounds simultaneously, dramatically reducing time-to-lead while minimizing solvent consumption and laboratory waste.
Whether you're pursuing drug discovery, materials science, or agrochemical applications, our integrated workflows combine intelligent library design with parallel synthesis and rapid purification to deliver optimized lead compounds faster than traditional methods.
Rational design of focused or diversity-oriented libraries, followed by parallel synthesis at multi-gram scales
Integration with screening assays for rapid characterization and hit identification
Iterative synthesis rounds to map structure-activity relationships and optimize potency and selectivity
From library design to final purification, we deliver complete end-to-end combinatorial synthesis services
Simultaneous synthesis of multiple compounds using automated liquid handling and robotic platforms
Efficient synthesis of diverse library pools with deconvolution strategies for hit identification
Generation of chemically diverse scaffolds to maximize hit rates in screening campaigns
Target-centric library design with refined structural constraints for lead optimization
Fragment-based screening and elaboration for structure-based drug design approaches
Rapid exploration of alternative core structures to improve properties and overcome resistance
State-of-the-art equipment and software systems for seamless synthesis workflows
Precision dispensing of reagents and solvents with high accuracy and minimal dead volume
Rapid heating for fast reaction kinetics and improved efficiency in library construction
Continuous-flow synthesis for precise control over reaction conditions and scalability
Automated flash chromatography and HPLC purification for rapid product isolation
Precision material handling with gravimetric or volumetric accuracy for consistent results
In-situ analytics including HPLC, GC-MS, and spectroscopy for quality assurance
Our parallel synthesis platform can efficiently handle libraries ranging from 50 to 10,000+ compounds, depending on the complexity of the synthetic route and desired scale. For split-and-pool approaches, we can generate even larger combinatorial libraries with thousands of diverse structures.
Timeline depends on library size, synthetic complexity, and purification requirements. A focused library of 200-500 compounds typically requires 6-12 weeks from design to final characterization. Larger diversity-oriented libraries may take 12-16 weeks. We work closely with clients to optimize timelines based on project constraints.
Yes, all compounds are routinely characterized by HPLC, LC-MS, NMR, and melting point analysis to confirm purity and identity. We can also provide additional characterization such as GC-MS, high-resolution MS, and structure confirmation by 2D NMR upon request. Quality assurance is built into every synthesis cycle.
Absolutely. We offer integrated workflows combining library synthesis with bioassay screening, enabling rapid hit identification and SAR studies. This closed-loop approach accelerates lead discovery by enabling iterative synthesis-screening cycles with quick turnaround times.
Let ChemContract's automated synthesis platform generate your next breakthrough compounds
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