Search 7,000+ Chemicals

Start typing to search our catalog

Combinatorial & Automated Synthesis

Accelerate discovery through high-throughput parallel synthesis, rapid optimization, and integrated screening workflows.

High-throughput synthesis capabilities
High-Throughput Capabilities

Accelerating Discovery Through Automation

ChemContract's combinatorial and automated synthesis platform enables rapid library design, synthesis, and screening at unprecedented scale. Our state-of-the-art automation technology generates hundreds to thousands of compounds simultaneously, dramatically reducing time-to-lead while minimizing solvent consumption and laboratory waste.

Whether you're pursuing drug discovery, materials science, or agrochemical applications, our integrated workflows combine intelligent library design with parallel synthesis and rapid purification to deliver optimized lead compounds faster than traditional methods.

01.

Library Design & Synthesis

Rational design of focused or diversity-oriented libraries, followed by parallel synthesis at multi-gram scales

02.

High-Throughput Screening

Integration with screening assays for rapid characterization and hit identification

03.

SAR Studies & Optimization

Iterative synthesis rounds to map structure-activity relationships and optimize potency and selectivity

Comprehensive Synthesis Solutions

From library design to final purification, we deliver complete end-to-end combinatorial synthesis services

Parallel Synthesis

Simultaneous synthesis of multiple compounds using automated liquid handling and robotic platforms

Split-and-Pool Libraries

Efficient synthesis of diverse library pools with deconvolution strategies for hit identification

Diversity-Oriented Synthesis

Generation of chemically diverse scaffolds to maximize hit rates in screening campaigns

Focused Libraries

Target-centric library design with refined structural constraints for lead optimization

Fragment Libraries

Fragment-based screening and elaboration for structure-based drug design approaches

Scaffold Hopping

Rapid exploration of alternative core structures to improve properties and overcome resistance

Integrated Automation Platform

State-of-the-art equipment and software systems for seamless synthesis workflows

Automated Liquid Handling

Precision dispensing of reagents and solvents with high accuracy and minimal dead volume

Microwave-Assisted Synthesis

Rapid heating for fast reaction kinetics and improved efficiency in library construction

Flow Chemistry Platforms

Continuous-flow synthesis for precise control over reaction conditions and scalability

High-Throughput Purification

Automated flash chromatography and HPLC purification for rapid product isolation

Automated Weighing & Dispensing

Precision material handling with gravimetric or volumetric accuracy for consistent results

Real-Time Reaction Monitoring

In-situ analytics including HPLC, GC-MS, and spectroscopy for quality assurance

Diverse Solutions Across Sectors

Drug Discovery & Development

Lead Identification
Lead Optimization
SAR Exploration
Selectivity Profiling

Materials Science & Specialty Chemicals

Catalyst Screening
Polymer Optimization
Material Discovery
Formulation Screening

Combinatorial Synthesis FAQs

What is the typical library size you can synthesize? +

Our parallel synthesis platform can efficiently handle libraries ranging from 50 to 10,000+ compounds, depending on the complexity of the synthetic route and desired scale. For split-and-pool approaches, we can generate even larger combinatorial libraries with thousands of diverse structures.

How long does a typical combinatorial synthesis project take? +

Timeline depends on library size, synthetic complexity, and purification requirements. A focused library of 200-500 compounds typically requires 6-12 weeks from design to final characterization. Larger diversity-oriented libraries may take 12-16 weeks. We work closely with clients to optimize timelines based on project constraints.

Do you provide analytical characterization of all synthesized compounds? +

Yes, all compounds are routinely characterized by HPLC, LC-MS, NMR, and melting point analysis to confirm purity and identity. We can also provide additional characterization such as GC-MS, high-resolution MS, and structure confirmation by 2D NMR upon request. Quality assurance is built into every synthesis cycle.

Can you integrate combinatorial synthesis with your screening services? +

Absolutely. We offer integrated workflows combining library synthesis with bioassay screening, enabling rapid hit identification and SAR studies. This closed-loop approach accelerates lead discovery by enabling iterative synthesis-screening cycles with quick turnaround times.

Combinatorial synthesis lab Automated synthesis

Let ChemContract's automated synthesis platform generate your next breakthrough compounds

ChemContract

Let's Build
Your Molecule

From discovery to commercial scale — our 500+ scientists are ready to accelerate your project.

24-Hour ResponseFast turnaround guaranteed
60+ FacilitiesGlobal R&D network
cGMP CompliantFDA-ready manufacturing

Request a Quote

Fill in the details and our team will get back to you.

Contact Information
Chemical Specifications
ChemContract
Online now

Hi there! How can we help you today?