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{4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride

CAS 938465-64-6 · Boronic Acid / Boronate Ester · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Boronic Acid / Boronate Ester

{4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride

Boronic Acids PharmaceuticalMedicinal ChemistryDiagnosticsAgrochemicalPolymerCatalysis
CAS Number 938465-64-6
Category Boronic Acid / Boronate Ester · Amine
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride

{4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride (CAS Number: 938465-64-6) is a boronic acid derivative valued for its role in carbon–carbon bond-forming reactions featuring a Benzene ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

The boron atom in this compound enables transmetalation with palladium catalysts, making it a cornerstone reagent for Suzuki coupling — one of the most widely used reactions in pharmaceutical process chemistry. Amines are among the most prevalent functional groups in drug molecules — over 80% of small-molecule pharmaceuticals contain at least one amine moiety. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.

Primary applications include suzuki–miyaura cross-coupling for biaryl and heterobiaryl synthesis and buchwald–hartwig amination for aryl c–n bond construction. This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, diagnostics sectors. Whether you require {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Benzene
Functional Groups: Boronic acidAmine (–NH₂/–NHR)Carboxylic acid (–COOH)Chlorine (C–Cl)
Salt Form: Hydrochloride

Boronic Acid / Boronate Ester Applications & Target Industries

How {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride is used across pharmaceutical and medicinal chemistry sectors

01

Suzuki–Miyaura cross-coupling for biaryl and heterobiaryl synthesis

02

Buchwald–Hartwig amination for aryl C–N bond construction

03

Improved handling characteristics versus the free base form

04

Proteasome inhibitor design in oncology drug development

05

Reductive amination with aldehydes and ketones for secondary amine synthesis

06

Direct formulation excipient in oral solid dosage forms

Target Industries: PharmaceuticalMedicinal ChemistryDiagnosticsAgrochemicalPolymerCatalysis

{4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride Specifications

Detailed specifications for this boronic acid / boronate ester, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride
Type Boronic Acid / Boronate Ester
Category Boronic Acid / Boronate Ester · Amine
Purity ≥95% (custom grades available)
Salt Form Hydrochloride
Complexity Moderate (4 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Boronic Acid / Boronate Esters

Handling Guidelines

Boronic acids are generally air-stable but some may be moisture-sensitive and undergo protodeboronation. Handle with gloves and safety glasses. Amines may have strong odors and can be corrosive to skin. Handle under adequate ventilation with chemical-resistant gloves and eye protection. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases.

Storage Conditions

Store in a tightly sealed container at room temperature under dry conditions. Protect from prolonged moisture exposure. Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed container. Protect from humidity.

Why Buy {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride From ChemContract?

Quality Assured

Every batch of {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride

What is {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride used for? +

{4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride is a boronic acid derivative valued for its role in carbon–carbon bond-forming reactions used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include suzuki–miyaura cross-coupling for biaryl and heterobiaryl synthesis and buchwald–hartwig amination for aryl c–n bond construction.

Where can I buy {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride in the USA? +

ChemContract Research is a trusted USA-based supplier of {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride? +

ChemContract Research supplies {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can I get {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride in a different salt form or as the free base? +

Yes. ChemContract Research can supply {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.

What reactions can I perform with the amine group in {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride? +

The amine functionality in {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.

How should I store {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride? +

Store in a tightly sealed container at room temperature under dry conditions. Protect from prolonged moisture exposure. Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed container. Protect from humidity. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride? +

The CAS Registry Number for {4-[(dimethylamino)methyl]phenyl}boronic acid hydrochloride is 938465-64-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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