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[R]-Pyrrolidine-3-carboxylic ethyl ester HCl

CAS 80028-44-0 · Ester · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days

Ester

[R]-Pyrrolidine-3-carboxylic ethyl ester HCl

Heterocycles PharmaceuticalPolymerFine ChemicalGreen ChemistryFormulationAnalytical Chemistry
CAS Number 80028-44-0
Category Ester · Hydrochloride Salt
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About [R]-Pyrrolidine-3-carboxylic ethyl ester HCl

[R]-Pyrrolidine-3-carboxylic ethyl ester HCl (CAS Number: 80028-44-0) is an ester with applications in prodrug design and protecting-group chemistry featuring a Pyrrolidine ring. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.

Primary applications include prodrug development to mask carboxylic acids and improve membrane permeability and improved handling characteristics versus the free base form. This compound serves researchers and manufacturers across the pharmaceutical, polymer, fine chemical sectors. Whether you require [R]-Pyrrolidine-3-carboxylic ethyl ester HCl for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Pyrrolidine
Functional Groups: Ester (–COOR)
Salt Form: Hydrochloride

Ester Applications & Target Industries

How [R]-Pyrrolidine-3-carboxylic ethyl ester HCl is used across pharmaceutical and polymer sectors

01

Prodrug development to mask carboxylic acids and improve membrane permeability

02

Improved handling characteristics versus the free base form

03

Protecting group for hydroxyl functionalities (acetate, benzoate)

04

Direct formulation excipient in oral solid dosage forms

05

Ring-opening polymerization monomer for biodegradable polymers

06

Crystalline form screening for polymorph and salt studies

Target Industries: PharmaceuticalPolymerFine ChemicalGreen ChemistryFormulationAnalytical Chemistry

[R]-Pyrrolidine-3-carboxylic ethyl ester HCl Specifications

Detailed specifications for this ester, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name [R]-Pyrrolidine-3-carboxylic ethyl ester HCl
Type Ester
Category Ester · Hydrochloride Salt
Purity ≥95% (custom grades available)
Salt Form Hydrochloride
Complexity Simple (1 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Esters

Handling Guidelines

Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases.

Storage Conditions

Store at room temperature in a tightly sealed container away from heat and open flame. Store at room temperature in a tightly sealed container. Protect from humidity.

Why Buy [R]-Pyrrolidine-3-carboxylic ethyl ester HCl From ChemContract?

Quality Assured

Every batch of [R]-Pyrrolidine-3-carboxylic ethyl ester HCl is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of [R]-Pyrrolidine-3-carboxylic ethyl ester HCl? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about [R]-Pyrrolidine-3-carboxylic ethyl ester HCl

What is [R]-Pyrrolidine-3-carboxylic ethyl ester HCl used for? +

[R]-Pyrrolidine-3-carboxylic ethyl ester HCl is an ester with applications in prodrug design and protecting-group chemistry used primarily in the pharmaceutical and polymer industries. Key applications include prodrug development to mask carboxylic acids and improve membrane permeability and improved handling characteristics versus the free base form.

Where can I buy [R]-Pyrrolidine-3-carboxylic ethyl ester HCl in the USA? +

ChemContract Research is a trusted USA-based supplier of [R]-Pyrrolidine-3-carboxylic ethyl ester HCl. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for [R]-Pyrrolidine-3-carboxylic ethyl ester HCl? +

ChemContract Research supplies [R]-Pyrrolidine-3-carboxylic ethyl ester HCl in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize [R]-Pyrrolidine-3-carboxylic ethyl ester HCl in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for [R]-Pyrrolidine-3-carboxylic ethyl ester HCl from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can I get [R]-Pyrrolidine-3-carboxylic ethyl ester HCl in a different salt form or as the free base? +

Yes. ChemContract Research can supply [R]-Pyrrolidine-3-carboxylic ethyl ester HCl as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.

How should I store [R]-Pyrrolidine-3-carboxylic ethyl ester HCl? +

Store at room temperature in a tightly sealed container away from heat and open flame. Store at room temperature in a tightly sealed container. Protect from humidity. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of [R]-Pyrrolidine-3-carboxylic ethyl ester HCl? +

The CAS Registry Number for [R]-Pyrrolidine-3-carboxylic ethyl ester HCl is 80028-44-0. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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