Frequently Asked
Common questions about (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID
What is (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID used for?
(R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID is a piperidine-containing compound — one of the most drug-prevalent saturated N-heterocycles used primarily in the pharmaceutical and cns therapeutics industries. Key applications include cns drug scaffold (present in donepezil, methylphenidate, fentanyl class) and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies.
Where can I buy (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID in the USA?
ChemContract Research is a trusted USA-based supplier of (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID?
ChemContract Research supplies (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID in custom quantities?
Yes. ChemContract Research offers custom synthesis services for (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID?
For amide bond formation from the carboxylic acid in (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
How do I remove the Boc group from (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID?
The Boc protecting group in (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
How should I store (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID?
Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID?
The CAS Registry Number for (R)-(+)-N-BOC-2-PIPERIDINECARBOXYLIC ACID is 28697-17-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
