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N-(tert-Butoxycarbonyl)-L-serine ?-Lactone

CAS 98541-64-1 · Boc-Protected · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Boc-Protected

N-(tert-Butoxycarbonyl)-L-serine ?-Lactone

Boc-Protected PharmaceuticalPeptide SynthesisFine ChemicalBiotechMedicinal ChemistryGreen Chemistry
CAS Number 98541-64-1
Category Boc-Protected · Lactone
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About N-(tert-Butoxycarbonyl)-L-serine ?-Lactone

N-(tert-Butoxycarbonyl)-L-serine ?-Lactone (CAS Number: 98541-64-1) is a Boc (tert-butyloxycarbonyl)-protected amino compound for orthogonal synthesis featuring a Lactone ring ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

The Boc group is removed cleanly with TFA or HCl in dioxane, making it orthogonal to Fmoc, Cbz, and Alloc protecting groups — essential for synthesizing complex peptide therapeutics. Lactones are among the most common structural motifs in bioactive natural products — from simple γ-butyrolactones to complex macrolide antibiotics — and the lactone/hydroxy acid equilibrium is leveraged in statin prodrug design. Chirality matters profoundly in drug action — enantiomers can differ by orders of magnitude in potency, and FDA guidelines increasingly require single-enantiomer development.

Primary applications include solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies and macrolide antibiotic intermediate synthesis (erythromycin, azithromycin class). This compound serves researchers and manufacturers across the pharmaceutical, peptide synthesis, fine chemical sectors. Whether you require N-(tert-Butoxycarbonyl)-L-serine ?-Lactone for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Lactone ring
Functional Groups: Boc protecting group
Stereochemistry: Defined Configuration

Boc-Protected Applications & Target Industries

How N-(tert-Butoxycarbonyl)-L-serine ?-Lactone is used across pharmaceutical and peptide synthesis sectors

01

Solid-phase peptide synthesis (SPPS) with orthogonal Boc/Fmoc strategies

02

Macrolide antibiotic intermediate synthesis (erythromycin, azithromycin class)

03

Enantiopure building block for single-enantiomer drug development

04

Multi-step pharmaceutical synthesis requiring selective amine deprotection

05

Statin-class drug intermediate (lactone ↔ hydroxy acid equilibrium)

06

Chiral resolution standard or chiral HPLC reference compound

Target Industries: PharmaceuticalPeptide SynthesisFine ChemicalBiotechMedicinal ChemistryGreen Chemistry

N-(tert-Butoxycarbonyl)-L-serine ?-Lactone Specifications

Detailed specifications for this boc-protected, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name N-(tert-Butoxycarbonyl)-L-serine ?-Lactone
Type Boc-Protected
Category Boc-Protected · Lactone
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (1 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Boc-Protecteds

Handling Guidelines

Boc-protected compounds are generally stable. TFA deprotection generates isobutylene gas — perform in a fume hood. Handle with standard precautions. Some lactones are sensitive to hydrolysis under acidic or basic conditions. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store at recommended temperature (often 2–8 °C) in a tightly sealed container. Protect from moisture. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy N-(tert-Butoxycarbonyl)-L-serine ?-Lactone From ChemContract?

Quality Assured

Every batch of N-(tert-Butoxycarbonyl)-L-serine ?-Lactone is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of N-(tert-Butoxycarbonyl)-L-serine ?-Lactone? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about N-(tert-Butoxycarbonyl)-L-serine ?-Lactone

What is N-(tert-Butoxycarbonyl)-L-serine ?-Lactone used for? +

N-(tert-Butoxycarbonyl)-L-serine ?-Lactone is a Boc (tert-butyloxycarbonyl)-protected amino compound for orthogonal synthesis used primarily in the pharmaceutical and peptide synthesis industries. Key applications include solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies and macrolide antibiotic intermediate synthesis (erythromycin, azithromycin class).

Where can I buy N-(tert-Butoxycarbonyl)-L-serine ?-Lactone in the USA? +

ChemContract Research is a trusted USA-based supplier of N-(tert-Butoxycarbonyl)-L-serine ?-Lactone. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for N-(tert-Butoxycarbonyl)-L-serine ?-Lactone? +

ChemContract Research supplies N-(tert-Butoxycarbonyl)-L-serine ?-Lactone in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize N-(tert-Butoxycarbonyl)-L-serine ?-Lactone in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for N-(tert-Butoxycarbonyl)-L-serine ?-Lactone from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What is the stereochemical purity of N-(tert-Butoxycarbonyl)-L-serine ?-Lactone? +

ChemContract Research supplies N-(tert-Butoxycarbonyl)-L-serine ?-Lactone with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

How do I remove the Boc group from N-(tert-Butoxycarbonyl)-L-serine ?-Lactone? +

The Boc protecting group in N-(tert-Butoxycarbonyl)-L-serine ?-Lactone is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.

How should I store N-(tert-Butoxycarbonyl)-L-serine ?-Lactone? +

Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store at recommended temperature (often 2–8 °C) in a tightly sealed container. Protect from moisture. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of N-(tert-Butoxycarbonyl)-L-serine ?-Lactone? +

The CAS Registry Number for N-(tert-Butoxycarbonyl)-L-serine ?-Lactone is 98541-64-1. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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