Frequently Asked
Common questions about N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester
What is N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester used for?
N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies.
Where can I buy N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester in the USA?
ChemContract Research is a trusted USA-based supplier of N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester?
ChemContract Research supplies N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester in custom quantities?
Yes. ChemContract Research offers custom synthesis services for N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
How do I remove the Boc group from N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester?
The Boc protecting group in N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
Why is fluorine important in N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester?
The fluorine atom(s) in N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester valuable in pharmaceutical development.
How should I store N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester?
The CAS Registry Number for N-(tert-Butoxycarbonyl)-(2S,4S)-4-fluoroproline methyl ester is 203866-16-4. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
