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Methyl4-cyano-3-methylbenzoate

CAS 25978-68-1 · Ester · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days

Ester

Methyl4-cyano-3-methylbenzoate

Esters PharmaceuticalPolymerFine ChemicalGreen ChemistryAgrochemicalResearch
CAS Number 25978-68-1
Category Ester · Nitrile
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About Methyl4-cyano-3-methylbenzoate

Methyl4-cyano-3-methylbenzoate (CAS Number: 25978-68-1) is an ester with applications in prodrug design and protecting-group chemistry. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids. The nitrile group is a bioisostere for both carboxylic acids and amides, and has emerged as a covalent warhead in next-generation kinase inhibitors like saxagliptin and neratinib.

Primary applications include prodrug development to mask carboxylic acids and improve membrane permeability and hydrolysis to carboxylic acids or amides under controlled conditions. This compound serves researchers and manufacturers across the pharmaceutical, polymer, fine chemical sectors. Whether you require Methyl4-cyano-3-methylbenzoate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Functional Groups: Nitrile (–C≡N)Ester (–COOR)

Ester Applications & Target Industries

How Methyl4-cyano-3-methylbenzoate is used across pharmaceutical and polymer sectors

01

Prodrug development to mask carboxylic acids and improve membrane permeability

02

Hydrolysis to carboxylic acids or amides under controlled conditions

03

Protecting group for hydroxyl functionalities (acetate, benzoate)

04

Click chemistry precursor for tetrazole formation (azide–nitrile cycloaddition)

05

Ring-opening polymerization monomer for biodegradable polymers

06

Covalent-warhead cysteine-targeting moiety in kinase inhibitor design

Target Industries: PharmaceuticalPolymerFine ChemicalGreen ChemistryAgrochemicalResearch

Methyl4-cyano-3-methylbenzoate Specifications

Detailed specifications for this ester, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name Methyl4-cyano-3-methylbenzoate
Type Ester
Category Ester · Nitrile
Purity ≥95% (custom grades available)
Complexity Simple (2 functional groups, 0 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Esters

Handling Guidelines

Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources. Some nitriles may release HCN upon decomposition. Handle in a well-ventilated fume hood with a cyanide antidote kit accessible.

Storage Conditions

Store at room temperature in a tightly sealed container away from heat and open flame. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases.

Why Buy Methyl4-cyano-3-methylbenzoate From ChemContract?

Quality Assured

Every batch of Methyl4-cyano-3-methylbenzoate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of Methyl4-cyano-3-methylbenzoate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about Methyl4-cyano-3-methylbenzoate

What is Methyl4-cyano-3-methylbenzoate used for? +

Methyl4-cyano-3-methylbenzoate is an ester with applications in prodrug design and protecting-group chemistry used primarily in the pharmaceutical and polymer industries. Key applications include prodrug development to mask carboxylic acids and improve membrane permeability and hydrolysis to carboxylic acids or amides under controlled conditions.

Where can I buy Methyl4-cyano-3-methylbenzoate in the USA? +

ChemContract Research is a trusted USA-based supplier of Methyl4-cyano-3-methylbenzoate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for Methyl4-cyano-3-methylbenzoate? +

ChemContract Research supplies Methyl4-cyano-3-methylbenzoate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize Methyl4-cyano-3-methylbenzoate in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for Methyl4-cyano-3-methylbenzoate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can the nitrile group in Methyl4-cyano-3-methylbenzoate be converted to other functional groups? +

Yes. The nitrile (–C≡N) in Methyl4-cyano-3-methylbenzoate can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.

How should I store Methyl4-cyano-3-methylbenzoate? +

Store at room temperature in a tightly sealed container away from heat and open flame. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of Methyl4-cyano-3-methylbenzoate? +

The CAS Registry Number for Methyl4-cyano-3-methylbenzoate is 25978-68-1. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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