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CIS-4-FLUORO PROLINE METHYL ESTER HCL

Fluorinated Compound · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days

Fluorinated Compound

CIS-4-FLUORO PROLINE METHYL ESTER HCL

Fluorinated PharmaceuticalDiagnostic ImagingAgrochemicalMaterials SciencePolymerFine Chemical
Category Fluorinated Compound · Ester
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About CIS-4-FLUORO PROLINE METHYL ESTER HCL

CIS-4-FLUORO PROLINE METHYL ESTER HCL is a fluorine-containing building block with enhanced metabolic stability with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.

Primary applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and prodrug development to mask carboxylic acids and improve membrane permeability. This compound serves researchers and manufacturers across the pharmaceutical, diagnostic imaging, agrochemical sectors. Whether you require CIS-4-FLUORO PROLINE METHYL ESTER HCL for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Functional Groups: Ester (–COOR)Fluorine (C–F)
Stereochemistry: Defined Configuration
Salt Form: Hydrochloride

Fluorinated Compound Applications & Target Industries

How CIS-4-FLUORO PROLINE METHYL ESTER HCL is used across pharmaceutical and diagnostic imaging sectors

01

Metabolic blocking strategy — fluorine substitution to improve drug half-life

02

Prodrug development to mask carboxylic acids and improve membrane permeability

03

Improved handling characteristics versus the free base form

04

Enantiopure building block for single-enantiomer drug development

05

PET radiotracer precursor ([¹⁸F]-labeling) for diagnostic imaging

06

Protecting group for hydroxyl functionalities (acetate, benzoate)

Target Industries: PharmaceuticalDiagnostic ImagingAgrochemicalMaterials SciencePolymerFine Chemical

CIS-4-FLUORO PROLINE METHYL ESTER HCL Specifications

Detailed specifications for this fluorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name CIS-4-FLUORO PROLINE METHYL ESTER HCL
Type Fluorinated Compound
Category Fluorinated Compound · Ester
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Salt Form Hydrochloride
Complexity Moderate (2 functional groups, 0 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Fluorinated Compounds

Handling Guidelines

Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame. Store at room temperature in a tightly sealed container. Protect from humidity. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy CIS-4-FLUORO PROLINE METHYL ESTER HCL From ChemContract?

Quality Assured

Every batch of CIS-4-FLUORO PROLINE METHYL ESTER HCL is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of CIS-4-FLUORO PROLINE METHYL ESTER HCL? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about CIS-4-FLUORO PROLINE METHYL ESTER HCL

What is CIS-4-FLUORO PROLINE METHYL ESTER HCL used for? +

CIS-4-FLUORO PROLINE METHYL ESTER HCL is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and prodrug development to mask carboxylic acids and improve membrane permeability.

Where can I buy CIS-4-FLUORO PROLINE METHYL ESTER HCL in the USA? +

ChemContract Research is a trusted USA-based supplier of CIS-4-FLUORO PROLINE METHYL ESTER HCL. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for CIS-4-FLUORO PROLINE METHYL ESTER HCL? +

ChemContract Research supplies CIS-4-FLUORO PROLINE METHYL ESTER HCL in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize CIS-4-FLUORO PROLINE METHYL ESTER HCL in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for CIS-4-FLUORO PROLINE METHYL ESTER HCL from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can I get CIS-4-FLUORO PROLINE METHYL ESTER HCL in a different salt form or as the free base? +

Yes. ChemContract Research can supply CIS-4-FLUORO PROLINE METHYL ESTER HCL as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.

What is the stereochemical purity of CIS-4-FLUORO PROLINE METHYL ESTER HCL? +

ChemContract Research supplies CIS-4-FLUORO PROLINE METHYL ESTER HCL with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

How should I store CIS-4-FLUORO PROLINE METHYL ESTER HCL? +

Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame. Store at room temperature in a tightly sealed container. Protect from humidity. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

Get CIS-4-FLUORO PROLINE METHYL ESTER HCL Delivered This Week

Get competitive pricing, custom quantities, and fast USA delivery. Our chemistry team is standing by to provide specifications, CoA documentation, and a tailored quote for your project.

Or call us directly: +1 (714) 732-8549

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