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4-Bromo-3-methoxypyridine HCl

CAS 109911-38-8 · Brominated Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Brominated Compound

4-Bromo-3-methoxypyridine HCl

Heterocycles PharmaceuticalFine ChemicalAgrochemicalResearchMedicinal ChemistryCatalysis
CAS Number 109911-38-8
Category Brominated Compound · Heterocyclic Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 4-Bromo-3-methoxypyridine HCl

4-Bromo-3-methoxypyridine HCl (CAS Number: 109911-38-8) is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling featuring a Pyridine ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

Aryl and alkyl bromides occupy a "Goldilocks zone" in cross-coupling — more reactive than chlorides yet more stable than iodides — making them the most commonly used coupling partners in process chemistry. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.

Primary applications include grignard reagent preparation via magnesium insertion into c–br bond and core scaffold in kinase inhibitor design for oncology therapeutics. This compound serves researchers and manufacturers across the pharmaceutical, fine chemical, agrochemical sectors. Whether you require 4-Bromo-3-methoxypyridine HCl for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Pyridine
Functional Groups: Bromine (C–Br)Alkoxy (–OR)
Salt Form: Hydrochloride

Brominated Compound Applications & Target Industries

How 4-Bromo-3-methoxypyridine HCl is used across pharmaceutical and fine chemical sectors

01

Grignard reagent preparation via magnesium insertion into C–Br bond

02

Core scaffold in kinase inhibitor design for oncology therapeutics

03

Improved handling characteristics versus the free base form

04

Palladium-catalyzed Suzuki, Heck, and Negishi cross-coupling

05

GPCR modulator development for CNS and cardiovascular indications

06

Direct formulation excipient in oral solid dosage forms

Target Industries: PharmaceuticalFine ChemicalAgrochemicalResearchMedicinal ChemistryCatalysis

4-Bromo-3-methoxypyridine HCl Specifications

Detailed specifications for this brominated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 4-Bromo-3-methoxypyridine HCl
Type Brominated Compound
Category Brominated Compound · Heterocyclic Compound
Purity ≥95% (custom grades available)
Salt Form Hydrochloride
Complexity Moderate (2 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Brominated Compounds

Handling Guidelines

Some brominated compounds may be lachrymatory or skin irritants. Handle in a fume hood with appropriate PPE. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases.

Storage Conditions

Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from humidity.

Why Buy 4-Bromo-3-methoxypyridine HCl From ChemContract?

Quality Assured

Every batch of 4-Bromo-3-methoxypyridine HCl is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 4-Bromo-3-methoxypyridine HCl? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 4-Bromo-3-methoxypyridine HCl

What is 4-Bromo-3-methoxypyridine HCl used for? +

4-Bromo-3-methoxypyridine HCl is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling used primarily in the pharmaceutical and fine chemical industries. Key applications include grignard reagent preparation via magnesium insertion into c–br bond and core scaffold in kinase inhibitor design for oncology therapeutics.

Where can I buy 4-Bromo-3-methoxypyridine HCl in the USA? +

ChemContract Research is a trusted USA-based supplier of 4-Bromo-3-methoxypyridine HCl. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 4-Bromo-3-methoxypyridine HCl? +

ChemContract Research supplies 4-Bromo-3-methoxypyridine HCl in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 4-Bromo-3-methoxypyridine HCl in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 4-Bromo-3-methoxypyridine HCl from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can I get 4-Bromo-3-methoxypyridine HCl in a different salt form or as the free base? +

Yes. ChemContract Research can supply 4-Bromo-3-methoxypyridine HCl as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.

What coupling reactions can I run with 4-Bromo-3-methoxypyridine HCl? +

As a brominated compound, 4-Bromo-3-methoxypyridine HCl is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

How should I store 4-Bromo-3-methoxypyridine HCl? +

Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from humidity. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 4-Bromo-3-methoxypyridine HCl? +

The CAS Registry Number for 4-Bromo-3-methoxypyridine HCl is 109911-38-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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