Frequently Asked
Common questions about (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride
What is (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride used for?
(2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.
Where can I buy (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride in the USA?
ChemContract Research is a trusted USA-based supplier of (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride?
ChemContract Research supplies (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride in custom quantities?
Yes. ChemContract Research offers custom synthesis services for (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride?
For amide bond formation from the carboxylic acid in (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
Can I get (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride in a different salt form or as the free base?
Yes. ChemContract Research can supply (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.
How should I store (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container. Protect from humidity. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride?
The CAS Registry Number for (2S,4R)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride is 60604-36-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
