Frequently Asked
Common questions about (2S)-pyrrolidine-2-carbonitrile trifluoroacetate
What is (2S)-pyrrolidine-2-carbonitrile trifluoroacetate used for?
(2S)-pyrrolidine-2-carbonitrile trifluoroacetate is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and prodrug development to mask carboxylic acids and improve membrane permeability.
Where can I buy (2S)-pyrrolidine-2-carbonitrile trifluoroacetate in the USA?
ChemContract Research is a trusted USA-based supplier of (2S)-pyrrolidine-2-carbonitrile trifluoroacetate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for (2S)-pyrrolidine-2-carbonitrile trifluoroacetate?
ChemContract Research supplies (2S)-pyrrolidine-2-carbonitrile trifluoroacetate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize (2S)-pyrrolidine-2-carbonitrile trifluoroacetate in custom quantities?
Yes. ChemContract Research offers custom synthesis services for (2S)-pyrrolidine-2-carbonitrile trifluoroacetate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Why is fluorine important in (2S)-pyrrolidine-2-carbonitrile trifluoroacetate?
The fluorine atom(s) in (2S)-pyrrolidine-2-carbonitrile trifluoroacetate confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like (2S)-pyrrolidine-2-carbonitrile trifluoroacetate valuable in pharmaceutical development.
Can the nitrile group in (2S)-pyrrolidine-2-carbonitrile trifluoroacetate be converted to other functional groups?
Yes. The nitrile (–C≡N) in (2S)-pyrrolidine-2-carbonitrile trifluoroacetate can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
How should I store (2S)-pyrrolidine-2-carbonitrile trifluoroacetate?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Store desiccated at –20 °C or as recommended. Protect from moisture to prevent deliquescence. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of (2S)-pyrrolidine-2-carbonitrile trifluoroacetate?
The CAS Registry Number for (2S)-pyrrolidine-2-carbonitrile trifluoroacetate is 473797-71-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
