CAS 406235-30-1 · Piperidine · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days
1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester (CAS Number: 406235-30-1) is a piperidine-containing compound — one of the most drug-prevalent saturated N-heterocycles featuring a Piperidine ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
The piperidine ring is the most common nitrogen heterocycle in FDA-approved drugs, appearing in over 70 marketed pharmaceuticals across CNS, cardiovascular, and oncology indications. Carboxylic acids are among the most synthetically versatile functional groups — they can be converted to amides, esters, acid chlorides, anhydrides, alcohols, and aldehydes in a single step. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids.
Primary applications include cns drug scaffold (present in donepezil, methylphenidate, fentanyl class) and amide bond formation via edc/hobt or hatu coupling in peptide synthesis. This compound serves researchers and manufacturers across the pharmaceutical, cns therapeutics, medicinal chemistry sectors. Whether you require 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester is used across pharmaceutical and cns therapeutics sectors
CNS drug scaffold (present in donepezil, methylphenidate, fentanyl class)
Amide bond formation via EDC/HOBt or HATU coupling in peptide synthesis
Prodrug development to mask carboxylic acids and improve membrane permeability
Enantiopure building block for single-enantiomer drug development
Conformationally-restricted amine for receptor binding optimization
Salt formation with amines to improve drug crystallinity and stability
Detailed specifications for this piperidine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Handle with standard precautions. Piperidine and some derivatives have strong amine odors. Use a fume hood. Acids may be corrosive or irritating. Handle with chemical-resistant gloves and eye protection. Use a fume hood for volatile acids. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.
Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.
Piperidine scaffolds like 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester are found in 70+ marketed drugs. We stock common analogs for rapid medicinal chemistry screening.
Every batch of 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester
1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester is a piperidine-containing compound — one of the most drug-prevalent saturated N-heterocycles used primarily in the pharmaceutical and cns therapeutics industries. Key applications include cns drug scaffold (present in donepezil, methylphenidate, fentanyl class) and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.
ChemContract Research is a trusted USA-based supplier of 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
ChemContract Research supplies 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.
The Piperidine ring system(s) in 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 1-Piperidinecarboxylic acid, 4-hydroxy-4-methyl-, 1,1-dimethylethyl ester is 406235-30-1. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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