Frequently Asked
Common questions about 1-BOC-L-pyroglutamic acid ethyl ester
What is 1-BOC-L-pyroglutamic acid ethyl ester used for?
1-BOC-L-pyroglutamic acid ethyl ester is a Boc (tert-butyloxycarbonyl)-protected amino compound for orthogonal synthesis used primarily in the pharmaceutical and peptide synthesis industries. Key applications include solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.
Where can I buy 1-BOC-L-pyroglutamic acid ethyl ester in the USA?
ChemContract Research is a trusted USA-based supplier of 1-BOC-L-pyroglutamic acid ethyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 1-BOC-L-pyroglutamic acid ethyl ester?
ChemContract Research supplies 1-BOC-L-pyroglutamic acid ethyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 1-BOC-L-pyroglutamic acid ethyl ester in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 1-BOC-L-pyroglutamic acid ethyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with 1-BOC-L-pyroglutamic acid ethyl ester?
For amide bond formation from the carboxylic acid in 1-BOC-L-pyroglutamic acid ethyl ester, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
How do I remove the Boc group from 1-BOC-L-pyroglutamic acid ethyl ester?
The Boc protecting group in 1-BOC-L-pyroglutamic acid ethyl ester is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
How should I store 1-BOC-L-pyroglutamic acid ethyl ester?
Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 1-BOC-L-pyroglutamic acid ethyl ester?
The CAS Registry Number for 1-BOC-L-pyroglutamic acid ethyl ester is 108963-96-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
