Frequently Asked
Common questions about 1-boc-isonipecotic acid hydrazide
What is 1-boc-isonipecotic acid hydrazide used for?
1-boc-isonipecotic acid hydrazide is a hydrazine-containing compound used as a versatile nitrogen nucleophile used primarily in the pharmaceutical and agrochemical industries. Key applications include synthesis of pyrazole and pyridazine heterocycles from 1,3-diketones and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies.
Where can I buy 1-boc-isonipecotic acid hydrazide in the USA?
ChemContract Research is a trusted USA-based supplier of 1-boc-isonipecotic acid hydrazide. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 1-boc-isonipecotic acid hydrazide?
ChemContract Research supplies 1-boc-isonipecotic acid hydrazide in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 1-boc-isonipecotic acid hydrazide in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 1-boc-isonipecotic acid hydrazide from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with 1-boc-isonipecotic acid hydrazide?
For amide bond formation from the carboxylic acid in 1-boc-isonipecotic acid hydrazide, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
How do I remove the Boc group from 1-boc-isonipecotic acid hydrazide?
The Boc protecting group in 1-boc-isonipecotic acid hydrazide is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
How should I store 1-boc-isonipecotic acid hydrazide?
Store refrigerated (2–8 °C) in a tightly sealed container. Protect from light, heat, and oxidizing agents. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 1-boc-isonipecotic acid hydrazide?
The CAS Registry Number for 1-boc-isonipecotic acid hydrazide is 187834-88-4. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
