Frequently Asked
Common questions about 1-Boc-3-(iodomethyl)azetidine
What is 1-Boc-3-(iodomethyl)azetidine used for?
1-Boc-3-(iodomethyl)azetidine is an iodo-substituted compound offering high reactivity in metal-mediated transformations used primarily in the pharmaceutical and nuclear medicine industries. Key applications include sonogashira and heck coupling with the lowest activation barrier among aryl halides and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies.
Where can I buy 1-Boc-3-(iodomethyl)azetidine in the USA?
ChemContract Research is a trusted USA-based supplier of 1-Boc-3-(iodomethyl)azetidine. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 1-Boc-3-(iodomethyl)azetidine?
ChemContract Research supplies 1-Boc-3-(iodomethyl)azetidine in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 1-Boc-3-(iodomethyl)azetidine in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 1-Boc-3-(iodomethyl)azetidine from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reactions can I run with 1-Boc-3-(iodomethyl)azetidine?
As a iodinated compound, 1-Boc-3-(iodomethyl)azetidine is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
How do I remove the Boc group from 1-Boc-3-(iodomethyl)azetidine?
The Boc protecting group in 1-Boc-3-(iodomethyl)azetidine is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
How should I store 1-Boc-3-(iodomethyl)azetidine?
Store refrigerated (2–8 °C) in a light-resistant, tightly sealed container under inert atmosphere to prevent degradation. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 1-Boc-3-(iodomethyl)azetidine?
The CAS Registry Number for 1-Boc-3-(iodomethyl)azetidine is 253176-94-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
